Levitra (Vardenafil) Drug interactions
ee also How To Use Levitra section
for drug-food interactions.
This drug should not be used with the following
medications because very serious (possibly fatal) interactions
may occur: nitrates (e.g., nitroglycerin, isosorbide), nitroprusside
(or any "nitric oxide donor" drugs), recreational drugs
called "poppers" containing amyl or butyl nitrite, alpha-blocker
medication (e.g., doxazosin, prazosin, terazosin).
If you are currently using any of these medications,
tell your doctor or pharmacist before starting vardenafil.
Before using this medication, tell your doctor
or pharmacist of all prescription and nonprescription/herbal products
you may use, especially of: other medications for impotence, drugs
that affect certain liver enzymes (CYP 3A4 substrates, inhibitors
and inducers, e.g., cimetidine, rifamycins, St. John's wort, certain
anti-seizure drugs), high blood pressure medicines.
If you are taking ritonavir, do not take more
than a 2.5mg dose of vardenafil in a 72 hour period. If you are
taking indinavir or high doses (400mg daily) of either ketoconazole
or itraconazole, do not take more than a 2.5mg dose of vardenafil
per day. If you are taking erythromycin or low doses (200mg daily)
of either ketoconazole or itraconazole, do not take more than
5mg dose of vardenafil per day. For more details contact your
doctor or pharmacist.
Other drugs besides vardenafil which may affect
the heart rhythm (QTc prolongation in the EKG) include dofetilide,
pimozide, amiodarone, quinidine, sotalol, procainamide, and sparfloxacin
among others. QTc prolongation can infrequently result in serious,
rarely fatal, irregular heartbeats. Consult your doctor or pharmacist
for details before taking vardenafil. Ask for instructions about
whether you need to stop any other QTc-prolonging drugs you may
be using in order to minimize the risk of this effect.
NOTES:
Do not share this medication with others, since they may have
a problem that is not effectively treated by this drug, or they
may have a condition that is complicated by this drug.
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